??? ????? ?? ????? ???? ??????? ????????? ???????? ?? ??????? ?? ????? ?????? ???????? ???????? ??????? ????????? ?????? ??????? ?????? ???????? ????? ????? ??? ?????? ????? ????? ???????. ????? ????? ??????? ?? ?????? ??????? ??????? ??????? ???????? ?????? ??????? / Biomedical Materials & Devices?.
???? ????? ????? ???? ????? ??????? ?????? ?? ??????. ???? ????? ?? ???????? ?? ??????? ????? ?????? ?? ?????? ?? ???????? ????? ?????? ?????? ?????????. ??? ????? ?????? ???????? ??????? ?????? ?????? ????? ???? ?????? ???????.
????? ????? ??????? ??? ???? ????? ??????? ?? ????? ??? ?????? ?? ????? ??? ????? ????? ?? ???? ????? ????? ?? ?????? ??????. ???? ???? ?????? ????? ?? ?????? ????????? ????????.
??? ??????? ??? ?????? AV1? ??? ???? ????? ?? ???????? (VI) ?? ???????? ????? (???????? ?????) ????????? ???????? ????? ????? ??????????. ????? ?????????? ???? ????? ??? ????? ????? ????? ????? MCF-7 ?? AV1 ???? ??? ??????? ????????? ???? ?????? ???? ????????? ???????? ??? ???? ????: ???? ???? IC50 ?? 10.3 ?????????/?? ????? 20.8 ?????????/?? ?????? ???????.
??? ??? ?????? ????????? ???????? ?????? ??? ???????? (??? ???????????)? ???? ?????? ?? ????? ?????? ?????? ????? ?????? ??????? ???????? ????? ???????? (IV) ????? ?????? ??????. ???? ?? ???? ??????? ??????? ?????? ??????: ?????? ?????? ?? ???? ????? ?????? ??????? ??????? ???? ??????? ?????????.
???????? ????? ??????? ??????? ?? ???? ????? ?????? ???????? ??????? ????? ??????? ?????? ???? ??????? ????????? ??????: ?? ????? ?????????? ?????? ?????? ?????????? ?????? ?????? ?? ???? AV1 ????????? ?????? ????? ?? ????? ????? ?????? ?????? ?? ????? ????????? ??? ?? ??????? ?? ??????? ?????? ????? ??????? ????????.
???? ???? ??????? ??????? ????? ????? ??? ????? ????? ?????? ????? ???????? ?????? DMBA. ????? ????????? ???? ????? ?? AV1 ????? 15 ????/??? ?? ???:
1. ??????? ????? ????????????? (???? ??????? ICDH ?SDH ?MDH ??? ??????? ?????? ?????? ???????).
2. ????? ??? ???? ??????? - ?????? ??????? ??????? ???????? (TBARS) ?????? ????? ????????? ??????? (SOD? ??????????? ????????????).
3. ???? ???? ?????????? - ????? ??????????? ?????????? ???????? (TNF-α? IL-1β? IL-6)? ???? ????? ??? ????? ????????.
?????? ?? ???? ??? ??? ?? ????????? ???? ?????? ?? ????? ?????? ?? ???? ??????: ?? ?????? ?? ????? ?? ????? ?? ????? ?? ????? ??? ??????? ????????? ??? ??? ????? ???????.
???????? ???????? ???????? (DFT) ?????? ????? ??????? ??????? ??????? (QSAR)? ???? ??????? ?? ?????? AV1 ?????? ?? ????? ?????? ?????? ?????? ?????? ?? ??????. ????? ??????? ??????? ???? ?????? ?? ????? ???????????? I? ??? ????? ???? ??????? ??????? ??????? ?????????. ???? ????? ??? ???????? ??? ??? ??????? ???????.
??????? ???????? ???????? ?????? ???? ?????? ?????? ??????????? ??? ?????????. ??? ?????? ????? ????? ??????? ??????? ????????? (QSAR)? ???? ???? ??????? ??? ?????? ?????????? ??????? ????????? ???????? ??????? ?????? ???? ??????? ?????? ?????? ???? ???????? ?????? ?????? ??????? ?? ???? ???? ?????????? ???? ??????????? ???????? – ??????? ????? ??????? ?? ?????? ?????? ????? ?????? ?? ?????: ?? ??? ???? ?????? ????????? ???????? ??? ?? ??????? ???? ??????. ????? QSAR ??? ???? ?????: ???? ???????? ????????? ??? ????? ????? ???????. ??? ????? ??? ????? ???????? ???? ????? ??????? ?????? ?????? ????? ????? ?? ?????? ???????? ???????? ??????? ??? ????????. ???? ??? ??????? ????? ??????? ??????? ???????: ??? ???? ??? ???????? ???????? ??? ????????? ?????? ?????? ??? ??????? ????????? ???????? ????? ????? ?????? ??????? ???? ????????
??? ?????? ???????? ?? ???????? AV2 ?AV3? ?????? ?? ?????? ?????? ???? ????? ??????? ???? ?? ???????? ????? ????? ???????? ???????? ???????????? ???? ????????? ???? ??? ?????.
????? ????? ?????? ?????? ???????? (IV) ??????? ?????? ????? ?? ?????? ?????????. ??? ???? ?????? AV1 ????? ??????? ???????. ????? ???????? ??? ?? ???? ???? ??? ???? ?? ???????? ???? ????? ???? ???? ????? ???? ?? ?????? ?????? ?? ??? ????? ???? ??????.
?? ????? ??? ?????? ????? ?? ???? ????? ????? ????? ???????? ?????? ?????????? ??? ???? ????? ????? ????? ???????? ??? ?????? ?? ???? ???????? ????????? ??? ?????.
????? ??????? ?????? ????? ???? ??? ?????? AV1 ?????? ?????? ?????? ??? ?????. ??? ??? ???? ??? ????????? ??? ????? ??? ?????? ?????? ?????? ??? ???? ?? ??????? ??????? ??????? ???????.